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#01 - Preventing Chronic Disease? Here's What Diabetes Patients Can Teach Us

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In this episode, John and Zach discuss how certain wearables could enable chronic disease prevention. Diabetes is presented as a case study we can learn from. John theorizes which steps researchers could follow to enable you and I to prevent other chronic diseases that are responsive to behavioral change. [0:00] Overview of personal data driving better healthcare; [2:05] Show and Episode Introduction; [2:53] Complexity of chronic disease prevention, research. Top four (+one) chronic diseases of focus; [7:10] Current issues with how we try to prevent chronic diseases. The importance of Diabetes[20:20] Overview of diabetes through a city building and repair analogy[27:48] Diabetes patients before 1920; Diabetes after 1920 when Insulin was successfully synthesized. 1940s - Physicians discover diabetes still causes an increase in chronic diseases. 1960s - Diabetes chronic disease prevention via extreme, constrained lifestyle? 1980s - The Diabetes Control and Complications Trial (DCCT) Revolution. 1990s - Diabetes management in the home. 2000s - Tightening glucose control to good effect. 2010s - Continuous Glucose Monitors (CGM) empower diabetes patients to determine their prevention strategy; [1:08:28] An 8-step Playbook: How diabetes-based chronic diseases were prevented and how other chronic diseases could follow a similar path.1) Identify a chronic condition worth preventing. 2) Researchers piece together the underlying “damage buildup” that’s -- at least partially -- causing the condition. 3) Researchers identify biomarkers (A1) that measure the current change in damage building up (like velocity, not position). 4) Researchers understand how to preferentially influence (B1) those biomarkers. 5) Researchers find a general solution (C1) for influencing the biomarkers to realistically minimize damage buildup and delay the resulting condition. 6) Create tools to monitor patient-specific biomarkers (A2) in their natural environment. 7) Patient and care team discover their patient-specific influence (B2) on those biomarkers. 8) Patient and care team find the patient-specific solution (C2) of very effective behaviors to improve the biomarkers, decrease the buildup of damage, and reduce the chance of chronic disease onset. And more!Fascinating discovery of insulin treatment, video: https://www.youtube.com/watch?v=O9Ixht8D9HIThe Discovery of Insulin by Michael Bliss: https://www.goodreads.com/book/show/1290513.The_Discovery_of_Insulin Diabetes Control and Complications Trial (DCCT) Overview: https://edic.bsc.gwu.edu/dcct-study Long Term DCCT Results: https://care.diabetesjournals.org/content/37/1/9 Continuous Glucose Monitors Outperform - IN CONTROL Trial: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(16)30193-0/fulltext Continuous Glucose Monitors Outperform - HypoDE Trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30297-6/fulltext Join the conversation via our interactive email newsletter! Subscribe at our website and explore past episodes and conversations while you’re there.Website: http://WeAreHereTomorrow.comPodcast: http://WeAreHereTomorrow.com/episodesNewsletter: http://eepurl.com/gNBZBn Facebook: https://fb.me/WAHTProject Twitter: https://twitter.com/WAHTProject Conversation Archive: https://us4.campaign-archive.com/home/?u=380cbdfa8ef19fab071b23bd2&id=19526581d8 Send Us Email: WeAreHereTomorrow@gmail.com