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Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova

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Pushing The Limits
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Aging is a gradual process of cell deterioration, but while it is a natural process, there are ways to hack its biological mechanisms. Certain supplements paired with sirtuin enzymes can lead to better well-being and suppress the effects of aging. In this episode, Dr Elena Seranova talks about the role of sirtuins in maintaining cell health. She also discusses how several supplements, including NMN and resveratrol, work to enhance the beneficial action of sirtuin. Listen to this episode to learn how to promote longevity and overall health.   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join their free live webinar on epigenetics.   Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching.   Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries,  to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/ For my other two best-selling books Running Hot and Running to Extremes chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   My Jewellery Collection For my gorgeous and inspiring sports jewellery collection ‘Fierce’, go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Find out how sirtuins play essential roles in promoting longevity. Learn how NAD influences sirtuin activity and how several compounds can increase NAD levels in the body. Discover the best methods for taking resveratrol supplements.   Resources Dr Elena's study on stem cell models of neurodegeneration for studying autophagy Study on NAD supplementation by Dr Elena's collaborator Research paper on the benefits of trehalose by Lisa's supervisor   Episode Highlights [03:24] Elena's Background Originally a psychologist, Elena ventured into neuroscience through her work on a neurofeedback device for patients with psychological and neurological diseases. She eventually pursued a master's degree in translational neuroscience and joined a biotech startup. She continued her studies through a PhD focusing on the molecular pathways of autophagy. [09:41] Sirtuins and Gene Expression Sirtuins are enzymes arising from various genes found across multiple species. They play crucial roles in evolution. Sirtuins assist in epigenetic regulation, where different cells have different active genes. Events such as taking a sauna or engaging in exercise change the environment of your cells. Evoking changes in gene expression hel
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