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Neural Implant podcast - the people behind Brain-Machine Interface revolutions

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This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space. Continue Reading >>
This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space. << Show Less
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Jotthe Kannappan on being a Venture Capitalist for minimally invasive medical technologies Jotthe Kannappan is an associate at Intuitive Ventures which is all about converging robotic systems, digital tools, and clinical needs in search of new ways to understand, diagnose, treat and manage disease. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways: "It's not about rejection. It's about enabling the best possible fit between an entrepreneur and an investor who is able to who's able to really do what the company needs for them" "The typical things that stand out are really well clearly articulated message again about an unmet medical needs is something that comes across really strongly in a first interaction with a VC" "It's a common pitfall to be a technology that's searching for a need as opposed to a need-driven technology." 1:00 "Do you want to talk about the thesis of Intuitive Ventures?" 2:30 "How long has Intuitive Surgical, the parents company been around? And do you want to talk about some of your investments so far?" 4:15 "What's your guys' thoughts on neurotechnology and brain-computer interfaces? What's attractive about neuro technology or maybe not attractive?" 6:00 "When a company might want to come to you and is looking for funding, what what are you looking for?" 8:45 Iris Biomedical ad sponsorship 9:30 "It sounds like the companies you invest in are a little bit further stage, or do you invest in early stage as well?" 10:15 "What's exciting for you guys at the moment?" 12:30 What percentage of people do you reject? 15:15 "What other tips or tricks are there to and you get your attention and maybe get a successful interaction out of it?" 17:15 "What are some of your biggest challenges?" 18:45 "If you had unlimited funding, what would you do with it?" 23:15 How do world political issues like the Covid pandemic and Ukraine-Russia war affect the investment landscape? 26:15 "Is there anything that we didn't talk about that you wanted to mention?"
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Jotthe Kannappan on being a Venture Capitalist for minimally invasive medical technologies Jotthe Kannappan is an associate at Intuitive Ventures which is all about converging robotic systems, digital tools, and clinical needs in search of new ways to understand, diagnose, treat and manage disease. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways: "It's not about rejection. It's about enabling the best possible fit between an entrepreneur and an investor who is able to who's able to really do what the company needs for them" "The typical things that stand out are really well clearly articulated message again about an unmet medical needs is something that comes across really strongly in a first interaction with a VC" "It's a common pitfall to be a technology that's searching for a need as opposed to a need-driven technology." 1:00 "Do you want to talk about the thesis of Intuitive Ventures?" 2:30 "How long has Intuitive Surgical, the parents company been around? And do you want to talk about some of your investments so far?" 4:15 "What's your guys' thoughts on neurotechnology and brain-computer interfaces? What's attractive about neuro technology or maybe not attractive?" 6:00 "When a company might want to come to you and is looking for funding, what what are you looking for?" 8:45 Iris Biomedical ad sponsorship 9:30 "It sounds like the companies you invest in are a little bit further stage, or do you invest in early stage as well?" 10:15 "What's exciting for you guys at the moment?" 12:30 What percentage of people do you reject? 15:15 "What other tips or tricks are there to and you get your attention and maybe get a successful interaction out of it?" 17:15 "What are some of your biggest challenges?" 18:45 "If you had unlimited funding, what would you do with it?" 23:15 How do world political issues like the Covid pandemic and Ukraine-Russia war affect the investment landscape? 26:15 "Is there anything that we didn't talk about that you wanted to mention?"
Benjamin Stecher on being a Parkinson's patient advocate Benjamin Stecher runs a blog called the Tomorrow Edition where he talks about his battle with Parkinson's disease. He has been implanted with a Deep Brain Stimulator an is also on the patient advisory board of Rune Labs where he gives them a perspective from the patient's point of view. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here*** Top 3 Takeaways:  "It got to the point where the Livadopa medication on-off fluctuations were so impairing to my daily life that I had maybe like an hour where I felt normal per day" "But to compare it to the medication now, it's night and day. It brought my baseline to the point where I felt more or less normal. Now I'm still not completely normal, things need to be optimized, but it's night and day compared to what it was before. It's very easy now for me to have these moments where I even forget that I have this disease at all " "There's nothing in my brain that anybody can point to and say, okay, this is what Parkinson's disease is. I don't believe that Parkinson's Disease exists" 1:00 Do you want to talk about your background? 2:45 "You were pretty young when you were diagnosed with Parkinson's disease. Do you want to talk about that?" 3:30 "What was the timeline of the disease?" 6:15 "You decided to crack your skull open and then put something in there. What was that kind of decision like? And then what were the results of that as well?" 7:30 Sponsorship by Ripple Neuro 7:45 "What's it been like and maybe how does it compare to the medication and was the results immediate?" 9:15 "You have an adaptive DBS implanted. Do you want to explain what this is?" 14:15 "Let's talk about your blog Tomorrow Edition" 15:30 "Let's talk about your work at Rune labs" 17:30 "Let's talk about your book to Brain Fables" 23:00 "If you had a magic wand, what would you be doing and what kind of improvements would you want to do?" 27:15 "Is there anything that we didn't talk about that you wanted to mention?" benjaminstecher@gmail.com
Dr Melanie Ecker on conformal soft neural electrodes in the gut-brain axis Dr Melanie Ecker is a professor at the University of North Texas focusing on smart polymers for biomedical applications. She has worked on conformal and biocompatible neural devices to study the electrophysiology of the enteric nervous system. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here*** Top 3 Takeaways: The neurons in the gut-brain axis have not been investigated much by neural probes because of the softness of the intestines "The beauty about the intestines is in comparison to the brain, our probes, the electrodes don't need to be that tiny" The key to recruiting lots of good student volunteers is to bring donuts to group meetings! 1:00 Do you want to introduce yourself and talk about your work? 2:30 "What are shape memory polymers and how does it relate to neurotechnology?" 4:30 What were you working on in the Voit lab and what are you working on now? 9:30 Sponsorship by Ripple Neuro 10:30 Are traditional neural probes too stiff for the intestines? 17:15 What are the conductive components of the flexible interfaces? 19:15 Do these conductive polymers last long in the body or are they dissolved quickly? 20:45 "If you had unlimited funding, what would you do?" 23:15 Do you have any tips on how to recruit so many students? 24:30 "Is there anything that we didn't cover that you wanted to mention?"
Dima Gazda and the prosthetic arm that learns with you by Esper Bionics Dima Gazda is the CEO and founder of Esper Bionics which is a company that makes a prosthetic arm that gains abilities overtime with you. They plan to use this 'simple' neurotech solution to springboard them solve other larger neurotech problems. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways:  We are building an ecosystem and will be building more products in addition to the robotic arm. Next will be a better user control system and then a robotic leg A physician can only add about 3000 patient-years of life but an engineer and entrepreneur can add millions because their inventions can impact more people Neurotechnology will be as big of a change for humanity as cars and computers were 0:30 Do you want to introduce yourself? 4:45 "So what is more difficult than a prosthetic arm that has many degrees of freedom?" 7:15 "Do you want to describe the device?" 8:30 "Does that improvement of control work only for a single user?" 10:30 How has the Russia-Ukraine conflict affected you as you are from Ukraine? 12:15 "Have you had any agreements with any governments like the Ukrainian government to recover injured soldiers?" 13:30 "What are some what are some of your biggest challenges?" 14:45 Iris Biomedical ad sponsorship 15:30 "Do you have any timelines?" 17:15 Do you want to talk about the number of lives improved by being an engineer versus being a physician? 22:00 What's the technology that would add a billion patient lives in the next 10 years? 29:00 "Is there anything that we didn't talk about that you wanted to mention?" Contact dg@esperbionics.com
Lindsay Hartland on recruiting and being recruited at the highest levels in neurotech Lindsay Hartland partners with Neuromodulation Device company Owners, Leaders, and Investors across the US & Europe to source the talent they need in order to succeed with Hanison Green Ltd. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways:  Sometimes it's better to not hire somebody but rather have a part-time position or even have them work for free in exchange for shares or honor "The main challenge any company will find when looking to grow their business is the best people tend to be working in jobs that they quite like. There's a talent shortage. There's not enough people to go around." "I used to assume that when you've got to get somebody more money, it's not. Most person's main driver is job fulfillment. They want to get up each morning and feel good about what they're going to work for and what the company's striving toward. Are they being developed, is there growth within that company? Money is important to all of us, but it's not the main driver." 0:30 Do you want to describe yourself? 3:00 "Why is this important for any startup to recruit?" 5:00 "How do you know who's a good person?" 7:15 Do you help early stage companies figure themselves out too? 9:45 "What's your opinion on that, hire a consultant versus hiring an employee?" 12:30 Iris Biomedical ad sponsorship 13:15 "Let's say hypothetically, I want to earn 250k how would I do that?" 15:45 "What's the mechanics of all this, of this poaching business that you're in?" 21:15 Do you sometimes find these leaders of companies in academia or in other fields or is the switch hard to make? 24:15 "How do you make money?" 30:15 "Is there anything that we didn't talk about?"
Anuj Bhardwaj on the noninvasive ultrasound therapy for treating inflammation and pain from SecondWave Systems Anuj Bhardwaj is the CEO of SecondWave Systems which is a wearable ultrasound noninvasive therapy especially for suppressing chronic inflammation and pain signals. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways:  "We're going to use a disposable coupling component that a patient uses to adhere this and couple it to the body for 18 minutes while they remain in a reasonably sedentary condition. They would do that once a day." "The cost of the healthcare system is often between one to $200,000 per year for patients that take biologics like Enbrel. So that's a huge burden on the system" "My advice to other companies like us would be to look at the SBIR program. We're very strong advocates of it. It's really been the main engine that launched us. I'd advise looking at NIH, BARDA, and others too. Then consider if they fit within the mission of what a company is doing and apply." 0:30 "Do you want to describe yourself and your technology?" 2:30 "Let's talk about the technology, who's it for?" 9:15 Iris Biomedical ad sponsorship 10:15 "You're not using electricity, but you're using ultrasound, which is something that's a little bit more rarely used. Why are you using this and how does it work?" 12:15 "What kind of treatments would you guys be able to provide?" 15:30 "So what fraction of the $100,000-$200,000 / year Rheumatoid Arthritis costs would you guys represent?" 16:30 Do you want to talk about the FDA approval process for a wearable? 18:15 Do you want to talk about your sources of funding so far? 22:30 "What is one of the biggest challenges in this work?" 25:00 "Are you looking for people to join or are you looking for anything in particular?"
Giovanni Lauricella how Neurotech Companies should find investments for their startups Giovanni Lauricella is the cofounder and managing partner at Lifeblood Capital where they find people, money and insight for MedTech startup companies. Giovanni comes on a second time to talk about how to find investment for neurotech startups ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways: "If you take bad money it could really ruin a company. Good money simplistically saying is- You find an investor who really knows how to add value to your company beyond simply writing you a check." "An investible story from the eyes of an investor is number one. And number two, when you finally do click send make sure that you're doing the due diligence on the investors with that who ultimately you're reaching out to. That they make sense." "Everything else after that can be shared throughout the diligence process, which typically takes 2, 3, 4, 5 months. You have ample time to share a lot of information with them once they're already interested." 1:00 "Do you want to introduce yourself again?" 4:30 "How do you raise money in a med tech startup?" 9:45 Iris Biomedical ad sponsorship 10:15 "What is an example of bad money and  how bad can bad get?" 18:15 "What are some tips for companies as they're raising money?" 22:00 "How do you get in contact with these people?" 28:15 "What's a wrong direction that a lot of people go down that could be easily fixed?" 35:15 "What percentage of that slide deck should be about the people in the company versus the technology? And then where can people find you?" Contact giovanni@lifebloodcapital.com
Dr. Talya Miron-Shatz on designing better neural devices using psychology and user interfaces Dr. Talya Miron-Shatz is an author, researcher, and speaker who is the author of "Your Life Depends on It: What you can do to make better choices about your health" which is a book about medical decision making. She talks about the data generated from neuro devices and what patients can do with it. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here*** Top 3 Takeaways: There is an opportunity to turn data generated by neuro medical devices into insights that are easy to digest "free, the data, free the data! And I was thinking - to whom? And what are they going to do with it? It's like someone delivering boxes upon boxes of papers to your front door. And you're like I don't know what to do with it. Free the data is great, but to help me make sense of it is even greater." "If you want to design for better usage and for better outcomes, you need to think psychology as well as technology" 0:45 "Do you want to introduce yourself?" 3:45 "How does your work fit into neuro technology?" 5:15 Sponsorship by Ripple Neuro 6:15 "What's your kind of solution forward with this?" 9:30 "The trend of medical devices and neurotechnology generating more data to have to sift through, is that helping the problem or is that worsening the problem" 11:15 Is app and user experience design of these new devices going to be one of the most important factors? 13:45 "So what's the solution for this? Is it just hiring more designers and psychologists?" 20:30 "What point in the development cycle of a medical device or neuro technology, should people start thinking about this?" 22:45 Is this different if the technology is implantable? 25:15 "Is there anything that we didn't talk about that you wanted to mention?" https://talyamironshatz.com/
Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform Dr Josh Siegle is a senior scientist working at the Allen Institute working on large-scale electrophysiology using tools like the Neuropixels probe. He is also heavily involved in the design and distribution of Open Ephys which is an open-source electrophysiology tool. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here*** Top three takeaways: "The dark matter problem is where the number of cells that we record is almost always less than the number of cells that we actually know to be in the tissue around the electrodes. This could be because there are neurons near the electrodes that just don't fire action potentials, their action potentials look very similar to other nearby neurons, or maybe the listening radius of our electrodes is not quite as large as we would expect it to be." "A big advantage of working at the Allen Institute is that we have very generous internal funding from Paul Allen. And so although we do apply for grants when it makes sense, for most people at the Allen Institute,  getting grant funding is not an existential threat to their research."  Open Ephys has recently started offering virtual 1-on-1 training sessions to help people get up and running with their tools. This is aligned with their goal of making open-source tools even more accessible throughout the neuroscience community. 0:45 Ladan introduces the episode and the guest, Dr. Josh Siegle 4:00 "What is the Neuropixels probe and how does it work? Why is it important?" 8:00 What capabilities does working with IMEC bring? 11:15 How exactly were you working with IMEC? 12:30 Sponsorship by Ripple Neuro 13:15 How does the pitch of the Neuropixels probe compare to biology? 16:45 What is the Allen Institute like? 20:15 What kind of mix of people work at the Allen Institute? 21:15 "What's the stated aims of the Institute again?" 22:00 What is the Open Ephys project you had worked on before? 27:45 What is the Open Ephys training like? 29:30 Do companies love or hate Open Ehpys? 31:00 "Is there anything that we didn't talk about that you wanted to mention?"
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